bacterial disease/anthrax

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683ba97231242d93219d32a8

Infectious

bacterial disease

anthrax

A 48-year-old male warehouse supervisor presents to a primary care clinic complaining of a progressively worsening skin lesion on his left forearm. He reports that several of his colleagues, who recently handled a shipment of imported animal hides, have developed similar skin changes. Approximately one week ago, he noticed a small, itchy papule, which then evolved into a fluid-filled blister. Over the past two days, the center of the lesion has turned dark and is now a painless, black, necrotic area, surrounded by significant non-pitting edema. He denies fever, chills, or respiratory symptoms. His vital signs are stable: temperature 37.20C, heart rate 78 bpm, blood pressure 130/85 mmHg, respiratory rate 16 breaths/min, oxygen saturation 98% on room air. Physical examination reveals a solitary, non-tender, circular lesion on the left ventral forearm measuring approximately 3 cm in diameter, characterized by a central black eschar with a surrounding rim of vesicles and considerable local edema. Regional axillary lymph nodes are palpable but not tender or enlarged. What is the most likely diagnosis and the appropriate initial antimicrobial management strategy for this patient?

Lab ParameterValueReference Range
White Blood Cell Count9.5 x 10^9/L4.0-11.0 x 10^9/L
Hemoglobin145 g/L130-170 g/L
Platelets280 x 10^9/L150-450 x 10^9/L
C-reactive protein8 mg/L<5 mg/L

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